DNA Replication… animated!

October 11, 2011 at 7:36 am Leave a comment

Hi everyone, just wanted to share an awesome video I was introduced to in class (shoutout to Zev Bryant)

This was shown as a motivation for the single-molecule study done on the replication machinery of bacteriophage T7.

Lee et al, “DNA primase acts as a molecular brake in DNA replication,” Nature, 439, 621-624 (2006).

To summarize the study, single-molecule experiments were set up in a very elegant fashion demonstrating that the primase prevents leading-strand synthesis from outpacing the slower enzymatic steps on the lagging strand by transiently halting progression of the replication fork.

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Playing around with posts on individual pages “10-fold symmetry???”

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